Microneedling မိုက်ခရိုအပ်နှင့် အရေပြား နှိုးဆွခြင်း

What is microneedling?

Microneedles (MNs) make a small tiny holes via stratum corneum for delivering drug into skin and it consists of needles of micron size ( arranged on a small patch) which allow hydrophilic high molecular weight compounds, reaching directly into epidermis or upper dermis delivering 100% of the loaded drug without pain.

Dimension of microneedles

150–1500 microns long

50–250 microns wide

1–25 microns tip thickness

Microneedle material and its properties

(1) silicon 

(2) silica glass

(3) metal

(4) creamic

(5) polymer

(6) carbohydrate (maltose, sucrose, xylitol, galactose, mannitol, trehalose)

Types of microneedle

Solid microneedle

Coated microneedle

Dissolving microcredit (biodegradable polymer)

Hollow microneedle

Types of Drugs used in microneedling

Oligoncleotides (short DNA or RNA molecules)

Peptides

Hormones

Cosmetics (Ascorbic acid, retinyl retinoate, eflornithine)

Analgesic (meloxicam)

Lignocain

Anticancer drugs (5FU, tamoxifen, gemcitabine)

Vaccine

Recovery time 

approximately 2-40 hours after microneedling

Pain threshold 

Less sensation of pain than 26-gauge needle.

Side effect

Temporary erythema, pain, and bleeding

Dr. Aye Min Htoo

(Dermatologist)